反应详情

N-(cis)-{2-[(aminoacetyl)amino]cyclohexyl}-4-(aminosulfonyl)benzamide hydrogen bromide, (61b), (70 mg) was dissolved in DMF (2.5 mL) prior to the addition of 3-chlorobenzenesulfonyl chloride (51 mg). After stirring overnight, EtOAc was added and the solution was washed with 1N HCl. The EtOAc was dried, filtered, and concentrated. Reverse phase HPLC purification (gradient elution, water/acetonitrile/TFA) of the resulting residue provided the title benzamide (25 mg). MS found: (M+H)+=530.1.

1. washthe solution was washed with 1N HCl
2. dry with materialThe EtOAc was dried
3. filtrationfiltered
4. concentrationconcentrated
5. customReverse phase HPLC purification (gradient elution, water/acetonitrile/TFA) of the resulting residue