反应详情

To a solution of ethyl 2-amino-4-bromo-6-(trifluoromethyl)phenyl[3-(trifluoromethyl)benzyl]carbamate (257.8 mg) in ethanol (10 ml) was added sodium hydride (60%) (48.7 mg). The reaction mixture was heated at reflux for 1.5 hours. To the reaction mixture was added 1N hydrochloric acid, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (247.7 mg, quantitative yield).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1.5 hours
3. extractionthe mixture was extracted with chloroform
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated in vacuo