反应详情

To a solution of 5-bromo-7-(trifluoromethyl)-1-[3-(trifluoromethyl)benzyl]-1,3-dihydro-2H-benzimidazol-2-one (171.9 mg) and copper(I) cyanide (76.3 mg) in N,N-dimethylformamide (10 ml) was heated at reflux for 11 hours. Copper(I) cyanide (51.0 mg) was further added, and the mixture was heated at reflux for 13 hours. To the reaction mixture was added saturated aqueous sodium bicarbonate solution, and the mixture was extracted 5 times with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (139.5 mg, 93%).

1. temperatureat reflux for 11 hours
2. temperaturethe mixture was heated
3. temperatureat reflux for 13 hours
4. extractionthe mixture was extracted 5 times with chloroform
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. concentrationconcentrated in vacuo