Hydrochloric Acid → HCID 131725119, compound

HRID 495721Notes

Reaction equation

HRID 495721 reaction equation
[CH:1]1([CH2:4][NH:5][S:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([NH:20][CH2:21][C@H:22]([OH:29])[C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)([CH3:19])[CH3:18])=[CH:12][CH:11]=2)(=[O:8])=[O:7])[CH2:3][CH2:2]1.[ClH:30]>CO.O1CCOCC1>[ClH:30].[ClH:30].[CH:1]1([CH2:4][NH:5][S:6]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:20][CH2:21][C@H:22]([OH:29])[C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)([CH3:19])[CH3:18])=[CH:14][CH:15]=2)(=[O:7])=[O:8])[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10202177HCID 10202177, compound

Product 1

HCID 131725119HCID 131725119, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of 71 mg of N-(cyclopropylmethyl)-N′-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-sulfamide (2B) in MeOH (1.5 mL) was added 4 N hydrochloric acid in p-dioxane (0.42 mL). After 10 minutes, the reaction solution was concentrated in vacuo to afford 75 mg of the title compound (2C) as a white solid; ms (Cl) m/z=419.4 (M+1). 1H NMR (CDCl3) was consistent with compound (2C).

Workup

  1. concentrationthe reaction solution was concentrated in vacuo

Sources & evidence

ORD record
ord-2609ca696db0426fa2ba7900aef3e0f2
Source dataset
uspto-grants-2005_09
Patent number
US06939867B2

Reaction notes

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