反应详情

温度

80 °C

5.0 g of 3-bromo-2-methyl-tetrahydrofuran-2-ol and 5.75 g of formamidine acetate were added to 15 ml of N,N-dimethylformamide. 5 g of diethylamine was slowly added to the reaction mixture, which was then stirred for about 4 hours at 80° C. and was distilled in vacuo for about 1 hour at the same temperature. The resulting oily residue was diluted with 25 ml of acetone. 4.95 g of oxalic acid was added to the reaction mixture, which was then stirred for about 1 hour. The resulting solid was filtered and washed with acetone to give 2.5 g of 2-(5-methyl-1H-imidazol-4-yl)ethanol oxalate (yield: 42%).

1. distillationwas distilled in vacuo for about 1 hour at the same temperature
2. additionThe resulting oily residue was diluted with 25 ml of acetone
3. addition4.95 g of oxalic acid was added to the reaction mixture, which
4. stirringwas then stirred for about 1 hour
5. filtrationThe resulting solid was filtered
6. washwashed with acetone