Hydrochloric Acid → HCID 9942941, compound

HRID 496076Notes

Reaction equation

HRID 496076 reaction equation
[ClH:1].[CH3:2][N:3]([C:11]1([CH2:14][CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[CH2:13][CH2:12]1)C(=O)OC(C)(C)C.CCOCC>O1CCOCC1>[ClH:1].[ClH:1].[CH3:2][NH:3][C:11]1([CH2:14][CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 17840539HCID 17840539, compound

Product 1

HCID 9942941HCID 9942941, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

20 ml of 4N hydrochloric acid in dioxane are added to a mixture containing 4.4 g of the product obtained in Step 2 in 20 ml of dioxane. Stirring is carried out for 4 hours at 20° C. and then 20 ml of ether are added. Crystallisation is observed. The crystals are filtered off, washed with ether and dried at 50° C. and 0.5 torr, allowing the expected product to be obtained.

Workup

  1. customCrystallisation
  2. filtrationThe crystals are filtered off
  3. washwashed with ether
  4. customdried at 50° C.
  5. customto be obtained

Sources & evidence

ORD record
ord-bd17b48e48e74149bd8023b94bce11f4
Source dataset
uspto-grants-2005_09
Patent number
US06943184B2

Reaction notes

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