1-Chloro-4-(chloromethyl)benzene → 4-Chlorobenzyl-2,5-dimethylpiperazine

HRID 496209Notes

Reaction equation

HRID 496209 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][CH:3]=1.[CH3:10][CH:11]1[CH2:16][NH:15][CH:14]([CH3:17])[CH2:13][NH:12]1>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:12]2[CH2:13][CH:14]([CH3:17])[NH:15][CH2:16][CH:11]2[CH3:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 78162,5-Dimethylpiperazine

Product 1

HCID 223135764-Chlorobenzyl-2,5-dimethylpiperazine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Was synthesized in the same way as A) from 1-chloro-4-chloromethyl-benzene (1.27 g, 7.89 mmol) and 2,5-dimethyl-piperazine (11.0 g, 8.77 mmol) in DMF. Yield 701 mg, 37%

Sources & evidence

ORD record
ord-af90bb379de045c59a3fab618ca40597
Source dataset
uspto-grants-2005_09
Patent number
US06943188B2

Reaction notes

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