Hydrochloric Acid → [Amino-[[2-methyl-4,5-bis(methylsulfonyl)benzoyl]amino]methylidene]azanium chloride
Reaction equation
C[O-].[Na+].[Cl-:4].[NH2:5][C:6]([NH2:8])=[NH2+:7].[CH3:9][S:10]([C:13]1[C:22]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:21][C:16]([C:17](OC)=[O:18])=[C:15]([CH3:27])[CH:14]=1)(=[O:12])=[O:11].Cl>CO.C1COCC1>[Cl-:4].[CH3:9][S:10]([C:13]1[C:22]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:21][C:16]([C:17]([NH:7][C:6]([NH2:8])=[NH2+:5])=[O:18])=[C:15]([CH3:27])[CH:14]=1)(=[O:12])=[O:11]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 20 °C
Procedure
87.4 ml of THF, were added with stirring to 50.4 g of a 30% sodium methoxide solution in methanol. 28.95 g of guanidinium chloride were subsequently introduced. The suspension was stirred at 16-24° C. for 2 h and cooled to 10° C., before 30.8 g of methyl 4,5-bismethanesulfonyl-2-methylbenzoate were introduced into the mixture. After the mixture had been stirred at 10° C. for 1 h, a corresponding amount of a hydrochloric acid solution was added to the mixture. Conventional work-up gave N-(4,5-bis-methanesulfonyl-2-methylbenzoyl)guanidinium chloride.
Workup
- additionwere introduced into the mixture
- stirringAfter the mixture had been stirred at 10° C. for 1 h
Sources & evidence
- ORD record
- ord-cf7def8212c549cd98a696702d9220ab
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06706921B2
Reaction notes
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