Potassium Carbonate → HCID 22320998, compound

HRID 496525Notes

Reaction equation

HRID 496525 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH3:8])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[NH:18]1[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]1>CN1CCCC1=O>[CH3:8][C:6]1[CH:7]=[C:2]([N:18]2[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]2)[CH:3]=[CH:4][C:5]=1[N+:9]([O-:11])=[O:10]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 949565-Fluoro-2-nitrotolueneHCID 982104-Hydroxypyrrolidine

Product 1

HCID 22320998HCID 22320998, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In a three necked flask, 38.78 g of 5-fluoro-2-nitrotoluene (0.25 mol), 41.4 g of potassium carbonate (0.3 mol) and 200 ml of N-methylpyrrolidinone were mixed. 26.13 g of 3-pyrrolidinol (0.3 mol) were added to this mixture. The heterogeneous mixture was agitated at ambient temperature for 12 hours. The reacting mixture was then poured on ice water. A yellow powder was then obtained. The powder was then filtered off and rinsed with water. After drying under vacuum with P2O5, 55.56 g of a yellow solid were obtained (yield) (95%).

Workup

  1. additionThe reacting mixture was then poured on ice water
  2. customA yellow powder was then obtained
  3. filtrationThe powder was then filtered off
  4. washrinsed with water
  5. dry with materialAfter drying under vacuum with P2O5

Sources & evidence

ORD record
ord-a316d633b2dd48b8b4761d905c41b1d2
Source dataset
uspto-grants-2005_09
Patent number
US06946005B2

Reaction notes

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