反应详情

温度

100 °C

After dissolving 56.4 g of 1-fluoro-4-nitrobenzene (0.4 mol) and 51.2 g of 3-acetamidopyrrolidine (0.4 mol) in 400 ml of NMP, 66.4 g of potassium carbonate (0.48 mol) were added under a nitrogen atmosphere and the mixture was heated at 100° C. for 18 hours. The reaction medium was allowed to cool and was then poured into 2 l of water. The yellow precipitate formed was filtered off, washed with water and then dried in a vacuum oven over P2O5. 100 g (100%) of N-[1-(4-nitrophenyl)pyrrolidin-3-yl]acetamide (1) was thus obtained in the form of a yellow solid.

1. additionwere added under a nitrogen atmosphere
2. temperatureto cool
3. customThe yellow precipitate formed
4. filtrationwas filtered off
5. washwashed with water
6. dry with materialdried in a vacuum oven over P2O5