HRID496640

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11

1,2-Dichloroethane

C2H4Cl2

HCID81138

Methanamine, N-methoxy-, hydrochloride

C2H8ClNO

结构：CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1C(=O)O

HCID14037017

(3S)-1-(tert-Butoxycarbonyl)-3-hydroxy-L-proline

C10H17NO5

PRODUCTS

生成物

结构：CON(C)C(=O)[C@@H]1[C@@H](O)CCN1C(=O)OC(C)(C)C

HCID57194245

未命名化合物

收率 76.1%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A mixture of compound 64 (8.42 g), N,O-dimethyl hydroxylamine HCl (10.66 g), DMAP (26.69 g), and EDC (10.47 g) in dichloromethane (500 ml) was stirred at ambient temperature for 16 hours. The reaction mixture was then applied directly to a silica flash column and eluted with ethyl acetate to give (2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxy-2-(N-methoxy-N-methylcarbamoyl)pyrrolidine (compound 65) as a clear gum(7.6 g).

WORKUP

后处理

washeluted with ethyl acetate