反应详情

温度

60 °C

82 mg (3.4 mmol) sodium hydride was added to an ice cooled solution of 500 mg (2.6 mmol) A1 and 342 mg (2.7 mmol) methoxyethoxymethylchloride in 5 ml dry dimethylformamide and the mixture was stirred at 60° C. for 8 hours. The solvent was distilled off and the residue was partitionated between aqueous ammonia and ethyl acetate. The organic layer was dried over sodium sulfate and evaporated to dryness yielding 370 mg (51%) A23, which was used without further purification.

1. distillationThe solvent was distilled off
2. dry with materialThe organic layer was dried over sodium sulfate
3. customevaporated to dryness
4. customyielding 370 mg (51%) A23, which
5. customwas used without further purification