反应详情

温度

90 °C

A mixture of 6-chloro-3-methoxy-5,9-diaza-benzo[c]fluoren-7-one (Reference Example 1c-2) (21 mg) and N-methyl-2,2′-diaminodiethylamine (WAKO PURE CHEMICAL: 3.3 mg) and potassium carbonate (10 mg) was suspended in N,N-dimethylformamide (0.5 ml) and stirred at 90° C. for thirteen hours under nitrogen gas. The mixture was evaporated to dryness. The residue was purified by silica gel column chromatography developed by dichloromethane-methanol=30:1 and dichloromethane-methanol-ammonia water (25%)=30:1:0.4. The desired product was obtained as a reddish powder.

1. customThe mixture was evaporated to dryness
2. customThe residue was purified by silica gel column chromatography