反应详情

At 65° C., 14 g of 2-methyl-6-nitrobenzaldoxime (80 mmol) are stirred in a mixture of 55 ml of 5% strength hydrochloric acid, 37 g of a 37% strength solution of formaldehyde, 50 ml of water and 100 ml of tetrahydrofuran for 24 hours. The phases are subsequently separated, and the dark phase is extracted with methylene chloride/water. The organic phase is dried with sodium sulfate and concentrated. This gives 10.1 g of crude product which is purified by filtration over silica gel using toluene as mobile phase.

1. customThe phases are subsequently separated
2. extractionthe dark phase is extracted with methylene chloride/water
3. dry with materialThe organic phase is dried with sodium sulfate
4. concentrationconcentrated
5. filtrationThis gives 10.1 g of crude product which is purified by filtration over silica gel