HCID 15551922, compound → 4-(2-Methylsulfonylphenyl)aniline

HRID 496790Notes

Reaction equation

HRID 496790 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)(=[O:4])=[O:3]>C1COCC1>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)(=[O:3])=[O:4]

Participants

3

Reactant 1

HCID 15551922HCID 15551922, compound

Product 1

HCID 108005164-(2-Methylsulfonylphenyl)aniline

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 17.0 g (61.3 mmol) of 2-methanesulfonyl-4′-nitrobiphenyl in 170 ml of THF is treated with 3.5 g of THF-moist Raney nickel and hydrogenated at room temperature and normal pressure until the completion of hydrogen absorption (18 hours). The catalyst is filtered off and the filtrate is evaporated. A colourless solid is obtained; FAB 248

Workup

  1. customnormal pressure until the completion of hydrogen absorption (18 hours)
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated
  4. customA colourless solid is obtained

Sources & evidence

ORD record
ord-b1fca8ac2d2347f9932cded2963bac23
Source dataset
uspto-grants-2005_09
Patent number
US06946489B2

Reaction notes

Loading…