Triethylamine → HCID 140382078, compound

HRID 496828Notes

Reaction equation

HRID 496828 reaction equation
N[C:2]1[C:6]([CH2:7][C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][NH:4][C:3]=1[C:14]([O:16][CH3:17])=[O:15].[C:18]([NH:22][C:23](=[N:26][C:27]([O:29][CH3:30])=[O:28])SC)([O:20][CH3:21])=[O:19].C([N:33](CC)CC)C>C(#N)C>[C:18]([N:22]([C:2]1[C:6]([CH2:7][C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][NH:4][C:3]=1[C:14]([O:16][CH3:17])=[O:15])[C:23]([NH:26][C:27]([O:29][CH3:30])=[O:28])=[NH:33])([O:20][CH3:21])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 98708Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamateHCID 10036874HCID 10036874, compound

Product 1

HCID 140382078HCID 140382078, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
5 °C

Procedure

Methyl 3-amino-4-(3-pyridylmethyl)-1H-pyrrole-2-carboxylate, obtained from Example 16 (2.31 g, 0.01 mol), N,N′-bis-carbomethoxy-S-methylisothiourea (2.27 g, 0.011 mol) and triethylamine (3.6 g, 0.35 mol) were stirred together in acetonitrile (50 mL) and cooled to 5° C. Mercuric chloride (2.98 g, 0.011 mol) was added and an immediate precipitate was observed. The mixture was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-439d56c742f2488383d55456a7e87fb5
Source dataset
uspto-grants-2005_09
Patent number
US06946554B2

Reaction notes

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