反应详情

The product of step (i) above was dissolved in toluene (10 ml). A solution of phosgene 2.0 M in toluene (10 ml) was added, the solution heated under reflux for 1 hour and cooled. Ethyl acetate and aqueous NaHCO3 solution were added, the organic phase separated, dried and concentrated to leave a residue which was purified by chromatography (dichloromethane:methanol, 95:5). The titled product was obtained as a solid (0.11 g).

1. temperaturethe solution heated
2. temperatureunder reflux for 1 hour
3. temperaturecooled
4. customthe organic phase separated
5. customdried
6. concentrationconcentrated
7. customto leave a residue which
8. customwas purified by chromatography (dichloromethane:methanol, 95:5)