反应详情

(+)-1-(2-methoxyphenyl)-4-[3-(cyclohexanecarbonyl)-3-(phenyl)butyl]piperazine (6.05 g, 13.9 mmol) was diluted with MTBE (120 mL) followed by addition of HCl (2.2 M solution in isopropanol, 6.3 mL, 13.9 mmol, prepared from 0.80 g of HCl gas in 10 mL of isopropanol). The mixture formed an oil/solid mixture which upon further stirring yielded a uniformly crystalline material. The mixture was suction-filtered and rinsed with MTBE to provide a white solid which was dried under vacuum at 45° C. (5.74 g, 96.2% ee).

1. customThe mixture formed an oil/solid mixture which
2. customyielded a uniformly crystalline material
3. filtrationThe mixture was suction-filtered
4. washrinsed with MTBE
5. customto provide a white solid which
6. customwas dried under vacuum at 45° C. (5.74 g, 96.2% ee)