Triethylamine → tert-Butyl 3-aminopropanoate

HRID 497007Notes

Reaction equation

HRID 497007 reaction equation
Cl.[C:2]([O:6][C:7](=[O:11])[CH2:8][CH2:9][NH2:10])([CH3:5])([CH3:4])[CH3:3].C(N(CC)CC)C>C(Cl)Cl>[C:2]([O:6][C:7](=[O:11])[CH2:8][CH2:9][NH2:10])([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 16218890Tert-butyl 3-aminopropanoate hydrochloride

Product 1

HCID 4192171tert-Butyl 3-aminopropanoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of β-alanine t-butyl ester hydrochloride (5 mmol, SIGMA) in CH2Cl2 (20 mL) was added triethylamine (5 mmol) at RT After the solution was stirred at RT for 15 mins, the precipitate formed was filtered and the CH2Cl2 was removed in vacuo to give the free amine, β-alanine t-butyl ester.

Workup

  1. customthe precipitate formed
  2. filtrationwas filtered
  3. customthe CH2Cl2 was removed in vacuo

Sources & evidence

ORD record
ord-0b961f3abcdd4277846e8487a30e5a18
Source dataset
uspto-grants-2005_09
Patent number
US06949534B2

Reaction notes

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