Hydrogen Bromide → HCID 22318113, compound

HRID 497034Notes

Reaction equation

HRID 497034 reaction equation
[BrH:1].CN(C)[CH:4]=[CH:5][C:6]([C:10]1[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=1)=[CH:7][C:8]#[N:9]>C(Cl)(Cl)Cl.ClCCl>[Br:1][C:8]1[CH:7]=[C:6]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)[CH:5]=[CH:4][N:9]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 73882160HCID 73882160, compound

Product 1

HCID 22318113HCID 22318113, compoundYield 62%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

Gaseous HBr was bubbled into a solution of 18 (3.6 g, 16.1 mmol) in chloroform for 15 minutes. The reaction was diluted with dichloromethane, washed with water, washed with brine, dried (MgSO4), and evaporated in vacuo to afford 3.2 g (62%) of 19 as an off-white solid.

Workup

  1. washwashed with water
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-9fa63202d6a14bb0b52b7bfb68c41335
Source dataset
uspto-grants-2005_09
Patent number
US06949544B2

Reaction notes

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