反应详情

2.9 g of 3-acetyl-1-chloro-2,5-dihydroxybenzene were dissolved in 29 ml of acetone, and 3.39 g of 1,1,3-trichloropropene, 4.3 g of potassium carbonate and 0.7 g of sodium iodide were added. The mixture was heated under reflux for 5 hours (monitored by TLC). The reaction mixture was then allowed to cool and concentrated using a rotary evaporator, and the resulting crude product was subjected to chromatographic purification. Yield: 6.1 g (99%)

1. temperatureThe mixture was heated
2. temperatureunder reflux for 5 hours (monitored by TLC)
3. temperatureto cool
4. concentrationconcentrated
5. customa rotary evaporator
6. customthe resulting crude product was subjected to chromatographic purification