反应详情

3.12 g of 5-benzoyloxy-3-chloro-1-iodo-2-[3-(5-trifluoromethylpyrid-2-yloxy)propyloxy]benzene were dissolved in 16 ml of tetrahydrofuran and 7.8 ml of methanol, and 3.9 ml of 2N aqueous sodium hydroxide solution were added. After 30 minutes of stirring at room temperature. 3.9 ml of 2N hydrochloric acid were added, and the reaction mixture was concentrated under reduced pressure. Saturated sodium chloride solution and ethyl acetate were added to the residue, and the mixture was shaken. The ethyl acetate phase was isolated, dried and concentrated. The resulting crude product was purified chromatographically. Yield: 2.03 g (80%)

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. additionSaturated sodium chloride solution and ethyl acetate were added to the residue
3. stirringthe mixture was shaken
4. customThe ethyl acetate phase was isolated
5. customdried
6. concentrationconcentrated
7. customThe resulting crude product was purified chromatographically