反应详情

2.23 g of 3-chloro-5-hydroxy-1-iodo-2-[3-(5-trifluoromethylpyrid-2-yloxy)propyloxy]-benzene were dissolved in 22 ml of acetone, and 0.79 g of 1,1,3-trichloropropene, 1.3 g of potassium carbonate and 0.27 g of sodium iodide were added. The mixture was stirred at room temperature for 20 hours (monitored by TLC). The reaction mixture was then concentrated using a rotary evaporator, and the resulting crude product was subjected to chromatographic purification. Yield: 2.62 g (95%)

1. concentrationThe reaction mixture was then concentrated
2. customa rotary evaporator
3. customthe resulting crude product was subjected to chromatographic purification