Hydrochloric Acid → HCID 22319741, compound

HRID 497576Notes

Reaction equation

HRID 497576 reaction equation
[OH-].[Na+].[CH2:3]([C:6]1[CH:30]=[CH:29][C:9]([C:10]([C:12]2[C:16]3[CH:17]=[C:18]([C:21]([O:23]C)=[O:22])[CH:19]=[CH:20][C:15]=3[O:14][C:13]=2[CH2:25][CH2:26][CH2:27][CH3:28])=[O:11])=[CH:8][CH:7]=1)[CH:4]=[CH2:5].Cl>CO.O1CCOCC1.O>[CH2:3]([C:6]1[CH:30]=[CH:29][C:9]([C:10]([C:12]2[C:16]3[CH:17]=[C:18]([C:21]([OH:23])=[O:22])[CH:19]=[CH:20][C:15]=3[O:14][C:13]=2[CH2:25][CH2:26][CH2:27][CH3:28])=[O:11])=[CH:8][CH:7]=1)[CH:4]=[CH2:5]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22319736HCID 22319736, compound

Product 1

HCID 22319741HCID 22319741, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

1.7 g of NaOH pellets are added to 8.1 g of methyl 3-(4-allylbenzoyl)-2-butylbenzofuran-5-carboxylate in 40 ml of methanol, 200 ml of dioxane and 40 ml of water. The mixture is stirred at ambient temperature for 24 hours. It is neutralized to pH 7 with concentrated hydrochloric acid and then evaporated. Water is added and the acid is regenerated with concentrated hydrochloric acid. Extraction is carried out three times with ether and the extracts are washed with water and then with an aqueous NaCl solution. They are dried over Na2SO4 and then concentrated.

Workup

  1. customevaporated
  2. additionWater is added
  3. extractionExtraction
  4. washthe extracts are washed with water
  5. dry with materialThey are dried over Na2SO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-d769b2f8b6f1421aa1a2e61730217f9d
Source dataset
uspto-grants-2005_09
Patent number
US06949583B2

Reaction notes

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