反应详情

Chlorotrimethylsilane (0.1 ml) was added to a suspension of 0.20 g of 3-(2-cyanophenyl)-5-(2-pyridyl)-2-methoxypyridine and 0.12 g of sodium iodide in 10 ml of acetonitrile and the mixture was stirred at room temperature for 3 hours. A saturated sodium bicarbonate solution was added to the mixture followed by extracting with ethyl acetate. The ethyl acetate layer was washed with water and a saturated saline solution and dried over magnesium sulfate. The solvent was concentrated in vacuo and the residue was purified by a silica gel column chromatography (ethyl acetate:hexane=1:1) to give 0.11 g of the title compound in pale yellow powder.

1. extractionby extracting with ethyl acetate
2. washThe ethyl acetate layer was washed with water
3. dry with materiala saturated saline solution and dried over magnesium sulfate
4. concentrationThe solvent was concentrated in vacuo
5. customthe residue was purified by a silica gel column chromatography (ethyl acetate:hexane=1:1)