反应详情

Isobutylamine (5.1 ml, 51.2 mmol) was added to a solution of 4-(2,3-epoxypropoxy) nitrobenzene (obtained as described in Synthetic Communications, 1994, 24, 833; 1.0 g, 5.12 mmol) in THF (1 ml). The solution was heated under reflux for 3 hours and then volatile material was removed by evaporation. The residue was dissolved in methanol (5 ml) and 10% palladium on carbon (0.50 g) and ammonium formate (3.23 g, 51.2 mmol) were added. The mixture was heated under reflux for 3 hours and then filtered through diatomaceous earth. The filtrate was concentrated under reduced pressure to give the product as dark brown oil (1.22 g, 100%), which was used without further purification. MS (MH+): 238.9.

1. temperatureThe solution was heated
2. temperatureunder reflux for 3 hours
3. customvolatile material was removed by evaporation
4. dissolutionThe residue was dissolved in methanol (5 ml)
5. temperatureThe mixture was heated
6. temperatureunder reflux for 3 hours
7. filtrationfiltered through diatomaceous earth
8. concentrationThe filtrate was concentrated under reduced pressure