Hydrochloric Acid → HCID 9967504, compound

HRID 498148Notes

Reaction equation

HRID 498148 reaction equation
Cl.[CH2:2]([O:12][CH2:13][CH2:14][CH2:15][C:16]1([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)OCC[O:17]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].CCOCC>C1COCC1>[CH2:2]([O:12][CH2:13][CH2:14][CH2:15][C:16]([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)=[O:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 22320902HCID 22320902, compound

Product 1

HCID 9967504HCID 9967504, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3 ml of HCl (1N) were added to a solution of 2.64 g (6.9 mmol) of 2-[3-(decyloxy)propyl]-2-(4-methoxyphenyl)-1,3-dioxolane obtained under b) in 50 ml of THF. The reaction mixture was heated at 40° for 2 h. After cooling down to room temperature, ether was added and the reaction mixture washed with a saturated solution of NaCl (3×). The organic phase was dried (Na2SO4) and concentrated to give 2.29 g (99%) of a slightly red oil that solidifies at 4°.

Workup

  1. temperatureThe reaction mixture was heated at 40° for 2 h
  2. washthe reaction mixture washed with a saturated solution of NaCl (3×)
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated
  5. customto give 2.29 g (99%) of a slightly red oil
  6. customthat solidifies at 4°

Sources & evidence

ORD record
ord-b94babddebc24d18b88cfb67e8b0c264
Source dataset
uspto-grants-2005_09
Patent number
US06949680B2

Reaction notes

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