Stannous chloride dihydrate → 1,1-Dimethylethyl N-(2-amino-4-chlorophenyl)carbamate

HRID 498191Notes

Reaction equation

HRID 498191 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[N+:15]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[NH2:15])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 539801451,1-Dimethylethyl N-(4-chloro-2-nitrophenyl)carbamate

Product 1

HCID 574562721,1-Dimethylethyl N-(2-amino-4-chlorophenyl)carbamate

Procedure

The title compound was prepared from (4-chloro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A5) (22.12 g, 85 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a red solid (13.93 g).

Sources & evidence

ORD record
ord-dcaeb5058b7a43129313c601914049a9
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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