(4-Chloro-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester → tert-Butyl (2-amino-4-chloro-5-fluorophenyl)carbamate

HRID 498192Notes

Reaction equation

HRID 498192 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([F:14])[C:11]([Cl:15])=[CH:10][C:9]=1[N+:16]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pt]>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([F:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69486584(4-Chloro-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 67375046tert-Butyl (2-amino-4-chloro-5-fluorophenyl)carbamate

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

The title compound was prepared from (4-chloro-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A6) (16.48 g, 56.7 mmol) by hydrogenation with 5% Pt/C according to the general procedure J (method a). Obtained as a brown solid (14.78 g).

Sources & evidence

ORD record
ord-7a092a66c7cf4cacac512288c4178497
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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