Stannous chloride dihydrate → tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

HRID 498209Notes

Reaction equation

HRID 498209 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[N+:16]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69489578HCID 69489578, compound

Product 1

HCID 69486983tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

Procedure

The title compound was prepared from (4-chloro-5-methyl-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A17) (4.45 g, 15.5 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a yellow solid (3.90 g, 98%).

Sources & evidence

ORD record
ord-ec715028ebe84840b9805c489dc25e6b
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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