Trifluoroacetic acid → HCID 22317600, compound

HRID 498526Notes

Reaction equation

HRID 498526 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH:21][C:22](=[O:38])[CH2:23][C:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27](C2C=NC=CC=2)[CH:26]=1)(C)(C)C.[C:40](O)([C:42](F)(F)F)=O>C(Cl)Cl>[F:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:24]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:8]4[CH:9]=[N:21][CH:22]=[CH:40][CH:42]=4)[CH:26]=3)[CH2:23][C:22](=[O:38])[NH:21][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589471HCID 86589471, compound

Product 1

HCID 22317600HCID 22317600, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2′-fluoro-3-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester (Example M26) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (127 mg).

Sources & evidence

ORD record
ord-27674feb927146b4a2b07fdce634c99e
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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