O-Phenylenediamine → HCID 22317983, compound

HRID 498566Notes

Reaction equation

HRID 498566 reaction equation
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].C([O:13][C:14](=O)[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]2[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=2)[CH:19]=1)=O)(C)(C)C>C1(C)C(C)=CC=CC=1>[CH3:30][C:26]1[CH:25]=[C:24]([C:20]2[CH:19]=[C:18]([C:16]3[CH2:15][C:14](=[O:13])[NH:8][C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=4[N:7]=3)[CH:23]=[CH:22][CH:21]=2)[CH:29]=[CH:28][N:27]=1

Participants

4

Reactant 2

HCID 7243O-PhenylenediamineHCID 694893073-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Product 1

HCID 22317983HCID 22317983, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

The title compound was prepared from commercially available 1,2-phenylendiamine (108 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (311 mg, 1.0 mmol) in xylene (20 ml) under reflux conditions for 2 h according to the general procedure M. Obtained as an off-white solid (230 mg, 70%).

Sources & evidence

ORD record
ord-6f7132fb004040b19e6676b3b51688ab
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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