Trifluoroacetic acid → HCID 22317833, compound

HRID 498676Notes

Reaction equation

HRID 498676 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=1[NH:20][C:21](=[O:37])[CH2:22][C:23](=O)[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)[CH:25]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:32]1[CH:33]=[CH:34][CH:35]=[C:30]([C:26]2[CH:25]=[C:24]([C:23]3[CH2:22][C:21](=[O:37])[NH:20][C:9]4[CH:10]=[C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:29]=[CH:28][CH:27]=2)[CH:31]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589363HCID 86589363, compound

Product 1

HCID 22317833HCID 22317833, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-4-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester (Example M179) (266 mg, 0.5 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (175 mg, 85%).

Sources & evidence

ORD record
ord-b3e7ab15fc534cbfb2fb691058f408e8
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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