Trifluoroacetic acid → HCID 22317685, compound

HRID 498692Notes

Reaction equation

HRID 498692 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH:19][C:20](=[O:38])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]2[CH:35]=[C:34]([CH3:36])[N:33]=[C:32]([CH3:37])[CH:31]=2)[CH:25]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:36][C:34]1[CH:35]=[C:30]([C:26]2[CH:25]=[C:24]([C:22]3[CH2:21][C:20](=[O:38])[NH:19][C:9]4[CH:10]=[C:11]([O:14][C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:29]=[CH:28][CH:27]=2)[CH:31]=[C:32]([CH3:37])[N:33]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589377HCID 86589377, compound

Product 1

HCID 22317685HCID 22317685, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester (Example M193) (230 mg, 0.423 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (97 mg, 54%).

Sources & evidence

ORD record
ord-b090c79ae43148b4a08cf0f4ea4631a1
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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