Trifluoroacetic acid → HCID 22317592, compound

HRID 498694Notes

Reaction equation

HRID 498694 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:23](=[O:39])[CH2:24][C:25](=O)[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=2)[CH:27]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:15]([O:14][C:12]1[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]2[NH:22][C:23](=[O:39])[CH2:24][C:25]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]4[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=4)[CH:27]=3)=[N:7][C:8]=2[CH:13]=1)[CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589379HCID 86589379, compound

Product 1

HCID 22317592HCID 22317592, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-propoxy-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M195) (359 mg, 0.626 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (223 mg, 81%).

Sources & evidence

ORD record
ord-f075369dffe54e71b0dae535109127ec
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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