Trifluoroacetic acid → HCID 22317404, compound

HRID 498709Notes

Reaction equation

HRID 498709 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][CH2:15][CH3:16])C(C(F)(F)F)=[CH:10][C:9]=1[NH:21][C:22](=[O:38])[CH2:23][C:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=2)[CH:26]=1)(C)(C)C.[C:40](O)([C:42]([F:45])([F:44])[F:43])=O>C(Cl)Cl>[CH2:14]([C:12]1[C:40]([C:42]([F:45])([F:44])[F:43])=[CH:10][C:9]2[NH:21][C:22](=[O:38])[CH2:23][C:24]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)[CH:26]=3)=[N:7][C:8]=2[CH:13]=1)[CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589394HCID 86589394, compound

Product 1

HCID 22317404HCID 22317404, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-propyl-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M210) (165 mg, 0.31 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (77 mg, 59%).

Sources & evidence

ORD record
ord-1e89bbdeb5b44a25a9ce0d6f0bd1bfe9
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…