Trifluoroacetic acid → HCID 22318029, compound

HRID 498720Notes

Reaction equation

HRID 498720 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH:14]=[CH2:15])[C:11]([C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=1[NH:20][C:21](=[O:39])[CH2:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:36]=[C:35]([CH3:37])[N:34]=[C:33]([CH3:38])[CH:32]=2)[CH:26]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:37][C:35]1[CH:36]=[C:31]([C:27]2[CH:26]=[C:25]([C:23]3[CH2:22][C:21](=[O:39])[NH:20][C:9]4[CH:10]=[C:11]([C:16]([F:18])([F:19])[F:17])[C:12]([CH:14]=[CH2:15])=[CH:13][C:8]=4[N:7]=3)[CH:30]=[CH:29][CH:28]=2)[CH:32]=[C:33]([CH3:38])[N:34]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589405(2-{3-[3-(2,6-Dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-5-vinyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 22318029HCID 22318029, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-5-vinyl-phenyl)-carbamic acid tert-butyl ester (Example M221) (175 mg, 0.316 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (104 mg, 76%).

Sources & evidence

ORD record
ord-9ea060f0dfb2450eb627aed76e2205cc
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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