Trifluoroacetic acid → 4-[3-(2,6-Dimethyl-pyridin-4-yl)-phenyl]-7-morpholin-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498839Notes

Reaction equation

HRID 498839 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:42])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:40]=[CH:39][N:38]=[C:37]([CH3:41])[CH:36]=2)[CH:30]=1)=O)(C)(C)C.[C:44](O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:44][C:39]1[CH:40]=[C:35]([C:31]2[CH:30]=[C:29]([C:27]3[CH2:26][C:25](=[O:42])[NH:24][C:9]4[CH:10]=[C:11]([C:20]([F:21])([F:23])[F:22])[C:12]([N:14]5[CH2:15][CH2:16][O:17][CH2:18][CH2:19]5)=[CH:13][C:8]=4[N:7]=3)[CH:34]=[CH:33][CH:32]=2)[CH:36]=[C:37]([CH3:41])[N:38]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589454HCID 86589454, compound

Product 1

HCID 223178804-[3-(2,6-Dimethyl-pyridin-4-yl)-phenyl]-7-morpholin-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-morpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M286) (377 mg, 0.615 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (211 mg, 69%).

Sources & evidence

ORD record
ord-73a5e4c7c4f5490e81dbf57b47fef24c
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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