Imidazole → HCID 21641203, compound

Temperature

0 °C

A stirred suspension of 1.2 grams of 60% sodium hydride (0.03 mole-in mineral oil) in 25 mL of THF was cooled to 0° C. to 5° C., and a solution of 2.0 grams (0.03 mole) of imidazole in 30 mL of THF was added dropwise. Upon completion of addition, the reaction mixture was stirred at 0° C. for an additional 15 minutes, then a solution of 4.7 grams (0.03 mole) of 2-(trimethylsilyl)ethoxymethyl chloride in 10 mL of THF was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature as it stirred during an 18 hour period. After this time, the reaction mixture was stirred with 50 mL of water, and the mixture was extracted with ethyl acetate. The extract was washed with an aqueous solution saturated with sodium chloride and was then dried with magnesium sulfate. The mixture was filtered and the filtrate was concentrated under reduced pressure to a residual oil. The residue was distilled under reduced pressure, yielding 3.8 grams of the subject compound; bp 71° C./0.1 torr. The NMR spectrum was consistent with the proposed structure.

1. temperaturewas cooled to 0° C. to 5° C.
2. additionUpon completion of addition
3. additionUpon completion of addition
4. temperatureto warm to ambient temperature as it
5. stirringstirred during an 18 hour period
6. extractionthe mixture was extracted with ethyl acetate
7. washThe extract was washed with an aqueous solution saturated with sodium chloride
8. dry with materialwas then dried with magnesium sulfate
9. filtrationThe mixture was filtered
10. concentrationthe filtrate was concentrated under reduced pressure to a residual oil
11. distillationThe residue was distilled under reduced pressure

ORD record

ord-fac27237b3ed4d78b655a07b0e5133a0

Source dataset

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07767667B2