反应详情

To a solution of 6′-chloro-[2,3′]bipyridinyl (0.275 g, 1.440 mmol) in acetonitrile (10 mL) was added piperazine (0.310 g, 3.600 mmol) and the mixture was stirred at reflux for 32 hours. The solvent was removed in vacuo. The residue was dissolved in dichloromethane and washed with saturated NaHCO3 solution (10 mL). Organic layer was separated, dried over MgSO4 and filtered. The filtrate was use in the next step without isolation of the product.

1. temperatureat reflux for 32 hours
2. customThe solvent was removed in vacuo
3. dissolutionThe residue was dissolved in dichloromethane
4. washwashed with saturated NaHCO3 solution (10 mL)
5. customOrganic layer was separated
6. dry with materialdried over MgSO4
7. filtrationfiltered