Piperazine → HCID 67523240, compound

HRID 499154Notes

Reaction equation

HRID 499154 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(#N)C>[N:14]1([C:2]2[N:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=3)=[CH:4][CH:3]=2)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 109543616'-Chloro-[2,3']bipyridinyl

Product 1

HCID 67523240HCID 67523240, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 6′-chloro-[2,3′]bipyridinyl (0.275 g, 1.440 mmol) in acetonitrile (10 mL) was added piperazine (0.310 g, 3.600 mmol) and the mixture was stirred at reflux for 32 hours. The solvent was removed in vacuo. The residue was dissolved in dichloromethane and washed with saturated NaHCO3 solution (10 mL). Organic layer was separated, dried over MgSO4 and filtered. The filtrate was use in the next step without isolation of the product.

Workup

  1. temperatureat reflux for 32 hours
  2. customThe solvent was removed in vacuo
  3. dissolutionThe residue was dissolved in dichloromethane
  4. washwashed with saturated NaHCO3 solution (10 mL)
  5. customOrganic layer was separated
  6. dry with materialdried over MgSO4
  7. filtrationfiltered

Sources & evidence

ORD record
ord-5427711f80b84704adce984d48eda270
Source dataset
uspto-grants-2010_08
Patent number
US07767677B2

Reaction notes

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