反应详情

6-(1H-Benzoimidazol-2-yl)pyridazin-3-ol (0.322 g, 1.570 mmol) was suspended in ethylene dichloride (10 mL). Phosphorus oxychloride was added (15 mL) and the mixture was stirred at reflux for 48 hours. All solvents were removed and the residue was washed with saturated NaHCO3 and extracted with ethyl acetate. The organic solution was dried, concentrated and purified by column chromatography to yield 0.075 g of 2-(6-chloro-pyridazin-3-yl)-1H-benzoimidazole (0.32 mmol, 20% yield).

1. temperatureat reflux for 48 hours
2. customAll solvents were removed
3. washthe residue was washed with saturated NaHCO3
4. extractionextracted with ethyl acetate
5. customThe organic solution was dried
6. concentrationconcentrated
7. custompurified by column chromatography