反应详情

温度

140 °C

A mixture of 2-(6-chloropyridazin-3-yl)-1H-benzoimidazole (0.280 g, 2.040 mmol) and piperazine (0.516 g, 6.000 mmol) in 1-methyl-2-pyrrolidone (35 mL) was heated to 140° C. with stirring for 30 minutes. The solvent was evaporated in vacuo, the residue was diluted with water (100 mL) and stirred for 15 minutes. A white precipitate was formed which was collected by filtration and dried to afford the title compound.

1. customThe solvent was evaporated in vacuo
2. additionthe residue was diluted with water (100 mL)
3. stirringstirred for 15 minutes
4. customA white precipitate was formed which
5. filtrationwas collected by filtration
6. customdried