Piperazine → HCID 67523199, compound

HRID 499159Notes

Reaction equation

HRID 499159 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[NH:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>CN1CCCC1=O>[N:17]1([C:2]2[N:7]=[N:6][C:5]([C:8]3[NH:12][C:11]4[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=4[N:9]=3)=[CH:4][CH:3]=2)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 86231906HCID 86231906, compound

Product 1

HCID 67523199HCID 67523199, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 2-(6-chloropyridazin-3-yl)-1H-benzoimidazole (0.280 g, 2.040 mmol) and piperazine (0.516 g, 6.000 mmol) in 1-methyl-2-pyrrolidone (35 mL) was heated to 140° C. with stirring for 30 minutes. The solvent was evaporated in vacuo, the residue was diluted with water (100 mL) and stirred for 15 minutes. A white precipitate was formed which was collected by filtration and dried to afford the title compound.

Workup

  1. customThe solvent was evaporated in vacuo
  2. additionthe residue was diluted with water (100 mL)
  3. stirringstirred for 15 minutes
  4. customA white precipitate was formed which
  5. filtrationwas collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-3e9a47a05b9e4d399430cf998581070c
Source dataset
uspto-grants-2010_08
Patent number
US07767677B2

Reaction notes

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