Piperazine → HCID 67523347, compound

HRID 499161Notes

Reaction equation

HRID 499161 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[N:11]=[N:12][C:13](Cl)=[CH:14][CH:15]=3)[NH:7][C:6]=2[CH:17]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>CN1CCCC1=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[N:11]=[N:12][C:13]([N:18]4[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]4)=[CH:14][CH:15]=3)[NH:7][C:6]=2[CH:17]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 59421029HCID 59421029, compound

Product 1

HCID 67523347HCID 67523347, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 6-chloro-2-(6-chloropyridazin-3-yl)-1H-benzoimidazole (0.212 g, 0.800 mmol) and piperazine (0.260 g, 3.000 mmol) in 1-methyl-2-pyrrolidone (15 mL) was heated at 140° C. and stirred for 30 minutes. The solvent was evaporated in vacuo, the residue was diluted with water (100 mL) and stirred for 15 minutes. A white precipitate was formed which was collected by filtration and dried to afford the title compound.

Workup

  1. customThe solvent was evaporated in vacuo
  2. additionthe residue was diluted with water (100 mL)
  3. stirringstirred for 15 minutes
  4. customA white precipitate was formed which
  5. filtrationwas collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-3da0c793423f4243a3bf7254e84bc25b
Source dataset
uspto-grants-2010_08
Patent number
US07767677B2

Reaction notes

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