反应详情

温度

80 °C

To a suspension of 4-[3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-ureido]benzoic acid ethyl ester (0.24 g, 0.71 mmol) in ethanol (4 mL) is added 1 N aq. NaOH solution (2 mL) and the mixture is heated at 80° C. for 2 hours. Then, 1 N HCl is added until pH 6 and the mixture is diluted with ethyl acetate. The organic phase is washed once with aqueous sodium chloride solution and dried over magnesium sulfate, filtered and evaporated under reduced pressure to give 0.19 g (0.59 mmol), 83% as white solid. ES+(m/z) 317 [M+H].

1. washThe organic phase is washed once with aqueous sodium chloride solution
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customto give 0.19 g (0.59 mmol), 83% as white solid