反应详情

温度

140 °C

8.3 g of potassium pentafluoropropionate and 9.8 g of CuI are introduced, under an inert atmosphere, into a 500 ml three-necked flask equipped with a Dean-Starck apparatus and a condenser. 90 ml of DMF and 110 ml of toluene are added. The medium is heated to 140° C. under nitrogen; 80 ml of toluene are distilled. The medium is then cooled to AT and then deoxygenated with nitrogen bubbling. 6 g of iodoanisole are then added and the medium is heated at 155° C. for 20 h. After a return to AT, the medium is diluted in 200 ml of a water/ethyl ether mixture. The medium is then filtered through Celite®. The organic phase is washed 3 times with water, dried over MgSO4 and then evaporated, to give 4.3 g of a brown oil.

1. customequipped with a Dean-Starck apparatus and a condenser
2. distillation80 ml of toluene are distilled
3. temperatureThe medium is then cooled to AT
4. customdeoxygenated with nitrogen bubbling
5. addition6 g of iodoanisole are then added
6. temperaturethe medium is heated at 155° C. for 20 h
7. additionAfter a return to AT, the medium is diluted in 200 ml of a water/ethyl ether mixture
8. filtrationThe medium is then filtered through Celite®
9. washThe organic phase is washed 3 times with water
10. dry with materialdried over MgSO4
11. customevaporated