反应详情

20 ml of a 10% sodium hydroxide solution are added to a suspension of 9.96 g of 1-benzyl-3-piperidone monohydrochloride hydrate in suspension in 200 ml of DCM. The medium is stirred, and the organic phase is separated by settling out and then washed with a saturated NaCl solution. After drying over MgSO4, the organic phase is concentrated. The gum obtained is taken up in 180 ml of DCE, 10.1 g of Boc-piperazine and then 15.9 g of NaBH(OAc)3 are added and the medium is stirred at AT for 12 h. The medium is concentrated and then taken up in EtOAc. The organic phase is washed twice with a saturated NaHCO3 solution, and then with a saturated NaCl solution. After drying over MgSO4, the organic phase is concentrated, to give 18.63 g of the expected product.

1. customthe organic phase is separated
2. washwashed with a saturated NaCl solution
3. dry with materialAfter drying over MgSO4
4. concentrationthe organic phase is concentrated
5. customThe gum obtained
6. stirringthe medium is stirred at AT for 12 h
7. concentrationThe medium is concentrated
8. washThe organic phase is washed twice with a saturated NaHCO3 solution
9. dry with materialAfter drying over MgSO4
10. concentrationthe organic phase is concentrated