Water → HCID 68455503, compound

HRID 499230Notes

Reaction equation

HRID 499230 reaction equation
C1CCC=CC=1.O.[C:8]([O:12][C:13]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][N:23]2C(OCC2C=CC=CC=2)=O)[CH2:17][CH2:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>CCO.[Pd]>[C:8]([O:12][C:13]([N:15]1[CH2:16][CH2:17][N:18]([CH2:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][NH:23]2)[CH2:19][CH2:20]1)=[O:14])([CH3:11])([CH3:9])[CH3:10]

Participants

6

Reactant 3

HCID 962WaterHCID 116051,3-CyclohexadieneHCID 68458309HCID 68458309, compound

Product 1

HCID 68455503HCID 68455503, compoundYield 83.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

14.5 ml of cyclohexadiene followed by 3.3 g of 10% Pd/C having a 50% water content are added, under an inert atmosphere, to a solution of 6.43 g of the compound obtained in step 6.1, in 50 ml of EtOH. The medium is stirred at AT for 48 hours and then filtered. The filtrate is evaporated, to give 3.63 g of the desired compound.

Workup

  1. filtrationfiltered
  2. customThe filtrate is evaporated

Sources & evidence

ORD record
ord-bcf47c7de33b4504ad255d764bf867f6
Source dataset
uspto-grants-2010_08
Patent number
US07767681B2

Reaction notes

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