Hydrochloric Acid → 1-[(1-methylpiperidin-2-yl)methyl]piperazine

HRID 499232Notes

Reaction equation

HRID 499232 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][N:17]2[CH3:22])[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[CH3:22][N:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]1[CH2:15][N:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68457042HCID 68457042, compound

Product 1

HCID 49146481-[(1-methylpiperidin-2-yl)methyl]piperazineYield 133.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1 ml of a 4M solution of HCl in dioxane is added to a solution of 3.28 g of the compound obtained in step 6.3, in 1 ml of dioxane. The medium is stirred at AT for 48 h. The medium is filtered, and the solid is rinsed with ether and then dried, to give 2.9 g of the desired compound.

Workup

  1. filtrationThe medium is filtered
  2. washthe solid is rinsed with ether
  3. customdried

Sources & evidence

ORD record
ord-038887936d82412693aec058f47b4d05
Source dataset
uspto-grants-2010_08
Patent number
US07767681B2

Reaction notes

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