Hydrochloric Acid → 4-Methoxybiphenyl-3-carboxylic acid

HRID 49949Notes

Reaction equation

HRID 49949 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].Cl>O1CCOCC1.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17834364Methyl 2-Methoxy-5-phenylbenzoate

Product 1

HCID 178343434-Methoxybiphenyl-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

0.84 g (3.33 mmol) of methyl 2-Methoxy-5-phenylbenzoate was stirred under heating at 80° C. in a solvent mixture of dioxane/water containing 4 M of hydrogen chloride for 7 hours. The solvent was evaporated to obtain the title compound.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-3a78d3bcc9ab4f0c9ba39807ab390c2c
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Reaction notes

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