Hydrochloric Acid → 2-Aminobenzothiazole-6-carboxylic acid hydrochloride

HRID 49950Notes

Reaction equation

HRID 49950 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11]([O:13]CC)=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[ClH:16]>>[ClH:16].[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 601008Ethyl 2-Aminobenzothiazole-6-carboxylate

Product 1

HCID 162363252-Aminobenzothiazole-6-carboxylic acid hydrochloride

Procedure

500 mg of ethyl 2-aminobenzothiazole-6-carboxylate (Maybridge Co., UK) was stirred in 20 ml of 4 M hydrochloric acid at 80° C. for 5 hours. The solvent was evaporated, and the residue was washed with a solvent mixture of ethyl acetate/hexane to obtain the title compound.

Workup

  1. customThe solvent was evaporated
  2. washthe residue was washed with a solvent mixture of ethyl acetate/hexane

Sources & evidence

ORD record
ord-dcb7343d5ea141779291e36914b13022
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Reaction notes

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